Risk stratification and surveillance in Barrett oesophagus
نویسندگان
چکیده
منابع مشابه
Value of cyclin A immunohistochemistry for cancer risk stratification in Barrett esophagus surveillance
The value of endoscopic Barrett esophagus (BE) surveillance based on histological diagnosis of low-grade dysplasia (LGD) remains debated given the lack of adequate risk stratification. The aim of this study was to evaluate the predictive value of cyclin A expression and to combine these results with our previously reported immunohistochemical p53, AMACR, and SOX2 data, to identify a panel of bi...
متن کاملBiomarkers for Risk Stratification of Neoplastic Progression in Barrett Esophagus
Barrett esophagus (BE) is caused by chronic gastroesophageal reflux and predisposes to the development of esophageal adenocarcinoma through different grades of dysplasia. Only a subset of BE patients will finally develop esophageal adenocarcinoma. The majority will therefore not benefit from an endoscopic surveillance program, based on the histological identification of dysplasia. Several studi...
متن کاملSurveillance in Barrett Esophagus
The only known precursor of the esophageal adenocarcinoma (EAC) is represented by the Barrett's esophagus (BE). EAC incidence has increased sharply in the last 4 decades. The annual conversion rate of BE to cancer is small but significant; therefore the identification of patients at a higher risk of cancer represents a dilemma. The endoscopic surveillance of BE aims to detect dysplasia and in p...
متن کاملSpectrum of clinico-pathological changes in Barrett oesophagus.
OBJECTIVES Barrett oesophagus is replacement of squamous epithelium to specialised intestinal metaplasia. It is associated with an increased risk for adenocarcinoma which develops through dysplasia. The aim of this retrospective study was to determine the relative age of occurrence and incidence of dysplasia in this part of our country. METHODS Between January 1999 and June 2002 we diagnosed ...
متن کاملEndoscopic surveillance of patients with Barrett esophagus.
I propose that a patient with a clinical diagnosis of Barrett’s oesophagus (BO) must have regularly endoscopic surveillance and protocol biopsy. BO is defined by endoscopically visible oesophageal columnar epithelium with intestinal metaplasia. The purpose of screening is detection of dysplastic change and early cancer, to allow early intervention and prevention of the suffering of symptomatic ...
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ژورنال
عنوان ژورنال: Nature Reviews Gastroenterology & Hepatology
سال: 2013
ISSN: 1759-5045,1759-5053
DOI: 10.1038/nrgastro.2013.237